drug withdrawals and transplanted organ rejection.

bridgeofsorrow
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Posts: 42
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From:

I was looking for specific details about both drug withdrawals, and transplanted organ rejection. All I want to know is what happens in real life. I don't trust what I see in movies or on TV. What's it like to go through withdrawals? What happens?

Also, what does a body do when it rejects an organ? How does it react? Symptoms?

I'm looking for more description of what it would look like, or feel like, not the scientific reasoning behind WHY it happens.

Thanks for any help!



stonecoyote
Why? Cos it's fun.
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Re: drug withdrawals and transplanted organ rejection.

Withdtrawal from heroin. First there's the head fuck, this can start straight after the last fix, intentional or inforced. You know that you are gonna feel shit and this brings about a sort of anxiety and restlessness. After approx twelve hours without the smack the restlesness becomes very real with muscles begining to cramp and involuntary moveing of the extremities. Constant yawning and watering of the eyes, wanting to sleep but knowing that there is no way, sleep is a thing of the past for at least a week. You can't concentrate on anything to distract you and your mind is constantly thinking about smack. I did my withdrawal through choice so I don't know if your mind can focus better if the possibility os scoring is removed through incarseration. Your whole body begins to sweat and tremble and strong spasms begin to hit home. Spasms is not totally correct as its more a case of your body trying to wrap itself into a huge knot. By the time youve been twenty four hours without drugs your body feels like there is a current of pain passing through you and each wave hits it brings with it nausea but you know if you vomit it will be the most painful thing you will ever experience, tough shit you have no choice, the heaving racking jolts of pain start with the occasional spewing forth of steaming hot black stomach bile. The years of constopation come to an end but this is not as comforting as you would think as first you begin passing thick rock hard stools that feel like they are teaering your anal passage apart as they pass but this is soon replaced by a simular steaming hot bile like fluid shooting from your ass, simular to that what you've been spewing that is. By this time time itself appears to have slowed to a painracked dragged out version of its former self and your brain is telling you to score as this is more than you can take. No sleep, constant twisting, shaking jolts, spasms, shit, vomit, pain, pain and more pain, depression, bargains with yourself and god, fever type hallucinations, depression, self hate, panic, shortness of breath, anxiety. I'm not sure when it happened but at some point all hope falls away from you and I remember actually picking up the phone. I must have picked the phone up a thousand times over that week. I managed to resist phoning for some smack but the possibility reduced me to tears, through the power of my wanting and how fuckin pathetic I felt.

There is nothing I have come across to compare to the joint physical and mental abuse your body and mind go through and I'm not doing a very good job of explaining the very real horrors of withdrawal. You are stripped bare and left feeling like a shitty fucked up corpse. The feelings of snakes in your guts and insects crawling under your skin that you've heard of are real, so are the feelings of someone trying to pull your muscles off of the bone.

After about a week you may start grabbing little snippets of sleep and you may beable to eat something lite. The deppression hangs around for a long time and the self hatred at what I became still lingers and returns every now and again. The whole thing about its like a dose of the flu is such utter nonsense. In the end I was like a skinny wraith with nothing of any value left but this is the closest I have ever come to having a clean slate and am still rebuilding myself. I did the rattle without any support groups etc but this is because I had kept my habit so tightly under wraps that I didn't  want to suddenly step under the spotlight and admit to others what I had become. I should imagine its different for everyone but others I have spoke to since all agree on one thing, for about four days it is nothing but pain and more pain poured on, so much so it takes you to places that you have never imagined existed within yourself, and man they are fucked up dark places.

 

At the end of the day I thought I could be different and use without getting hooked, DOH, yeh right.

 

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damien_mayfair
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Posts: 1199
Joined: 2006-08-21
From:
Re: drug withdrawals and transplanted organ rejection.

stonecoyote wrote:

Withdtrawal from heroin. First there's the head fuck, this can start straight after the last fix, intentional or inforced. You know that you are gonna feel shit and this brings about a sort of anxiety and restlessness. After approx twelve hours without the smack the restlesness becomes very real with muscles begining to cramp and involuntary moveing of the extremities. Constant yawning and watering of the eyes, wanting to sleep but knowing that there is no way, sleep is a thing of the past for at least a week. You can't concentrate on anything to distract you and your mind is constantly thinking about smack. I did my withdrawal through choice so I don't know if your mind can focus better if the possibility os scoring is removed through incarseration. Your whole body begins to sweat and tremble and strong spasms begin to hit home. Spasms is not totally correct as its more a case of your body trying to wrap itself into a huge knot. By the time youve been twenty four hours without drugs your body feels like there is a current of pain passing through you and each wave hits it brings with it nausea but you know if you vomit it will be the most painful thing you will ever experience, tough shit you have no choice, the heaving racking jolts of pain start with the occasional spewing forth of steaming hot black stomach bile. The years of constopation come to an end but this is not as comforting as you would think as first you begin passing thick rock hard stools that feel like they are teaering your anal passage apart as they pass but this is soon replaced by a simular steaming hot bile like fluid shooting from your ass, simular to that what you've been spewing that is. By this time time itself appears to have slowed to a painracked dragged out version of its former self and your brain is telling you to score as this is more than you can take. No sleep, constant twisting, shaking jolts, spasms, shit, vomit, pain, pain and more pain, depression, bargains with yourself and god, fever type hallucinations, depression, self hate, panic, shortness of breath, anxiety. I'm not sure when it happened but at some point all hope falls away from you and I remember actually picking up the phone. I must have picked the phone up a thousand times over that week. I managed to resist phoning for some smack but the possibility reduced me to tears, through the power of my wanting and how fuckin pathetic I felt.

There is nothing I have come across to compare to the joint physical and mental abuse your body and mind go through and I'm not doing a very good job of explaining the very real horrors of withdrawal. You are stripped bare and left feeling like a shitty fucked up corpse. The feelings of snakes in your guts and insects crawling under your skin that you've heard of are real, so are the feelings of someone trying to pull your muscles off of the bone.

After about a week you may start grabbing little snippets of sleep and you may beable to eat something lite. The deppression hangs around for a long time and the self hatred at what I became still lingers and returns every now and again. The whole thing about its like a dose of the flu is such utter nonsense. In the end I was like a skinny wraith with nothing of any value left but this is the closest I have ever come to having a clean slate and am still rebuilding myself. I did the rattle without any support groups etc but this is because I had kept my habit so tightly under wraps that I didn't  want to suddenly step under the spotlight and admit to others what I had become. I should imagine its different for everyone but others I have spoke to since all agree on one thing, for about four days it is nothing but pain and more pain poured on, so much so it takes you to places that you have never imagined existed within yourself, and man they are fucked up dark places.

 

At the end of the day I thought I could be different and use without getting hooked, DOH, yeh right.

 

my respect for you has grown after reading this.



sheusedtobeblonde
stuck in the 60's
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Posts: 91
Joined: 2008-07-23
From: venus
Re: drug withdrawals and transplanted organ rejection.

i did a project on organ transplants so i should know.

 

what i remember is that the immune system attacks the organ like its any sort of foreign object or virus in your body.

 

it tries to destroy it, that's all i know.

 

and that there are two types of rejection.. acute rejection... the kind where just right away your body is like.. .Fuck It.

 

and then chronic rejection where your body can live off the organ until a new one is found, but it's not living properly. like its trying to destroy it at the same time as living off of it.

one can live off a faulty lung accompanied with breathing machines until a proper lung is found for them.

but the time period varies depending on the case.



fortune_wookie
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Posts: 216
Joined: 2004-06-16
From:
Re: drug withdrawals and transplanted organ rejection.

In the words of Arrested Development...graft vs host disease.  Biggest organ in the body...skin.  Skin graft and rejection.  Cool thing about skin grafts is you can use your own skin, and since it is yours, it decreases the chance your body will reject it.

In other things, such as kidney transplants, ect., it isn't your unique tissue and makeup, so your body rejects it.  It's been so long since I studied this so forgive me if I'm rusty.

What happens if your immune system rejects the orgran, since it is foreign.  So you need to take immunosuppressants to lower your body's natural ability to fight and attack.  People also get steroids, I believe, because like your prednisone and such, decrease inflamation.  Think, when your body gets inflamed, it's fighting some kind of injury.  When you use an anti-inflamatory, you lower your immunity, and it puts you at an increased risk for infection.

People who get transplants also go on drugs to supplement their ability to fight infections while their immunity is down.  Antivirals, like your "cyclovirs"  (TV herpes drugs), antifungals (Diflucan...popular all around), and your basic antibiotics (Bactrim and Septra are commonly used because they also kick UTI's in the ass).

Side effects kind of suck.  Like the increased risk for infection.  Fuckin steroids make your bloated and give you pseudo cushings or whatever it is (You get a nice fat round face called Moon Face.  Not to be confused with Robert Downey Jr. Black Face).  Oh, an another biggie is hyperglycemia (higher blood sugar) so your also looking at insulin at some point during your hospital stay prophylactically.

What kind of drug withdrawal stuff you wanna know?  I can tell you all about ETOH (alcohol withdrawal) and how that is treated.

Anyways, the transplant pt is in for  along road, specially if they are going through drug withdrawal (which, if it is known that they are a drug user, it is HIGHLY UNLIKELY they will ever get an organ donated if they are on a list.  A family member could still donate, which if they were a match, would work.  But a known drug user getting an organ of any organ list, probably not.  It would be viewed as a waste.)

Go to google and put in "drugs after organ transplant."  The first web site is through the Mayo Clinic and it is very helpful.

Also, like most things, there is probably a blog type deal with people who were organ recipients who share their experience. 

Good luck.

 

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PGoutis01
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Re: drug withdrawals and transplanted organ rejection.

Remember everybody - this is the Research Department.  Please stay on topic.

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