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Best Drug Related Movie

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What is your favorite drug related movie? i personally think Requiem For A Dream is the best.
to count as a drug related movie, drugs have to serve as a major plot element. movies like Almost Famous, which had drugs in it, does not count because the plot wasn't affected by them.

here are some examples:

Requiem for a dream
Blow
Fear and Loathing in Las Vegas
Traffic
Trainspotting
Half Nelson
Scarface
Reefer Madness
Any Cheech and Chong Movie
Drugstore Cowboy

and many others.